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Multiscale and Multiphysics analysis of the deformation of cellular arrangements under an electric-field excitation : application to electroporation

Danish Shamoon 1
1 Lab-STICC_UBO_MOM_MF
Lab-STICC - Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance, UBO - Université de Brest
Abstract : This thesis concerns the numerical analysis of electric field induced physical processes arising in biological cell membranes in N-cell assemblies with various applied voltage characteristics using finite element modeling. The study allows us to explore how the electrodeformation and electroporation phenomena are affected by cellcell proximity and asymmetry in the N-cell assembly.It is shown that the presented approach has a significant scope for predicting the behavior of cells in suspension or tissue under an electric stimulus.The results are in good agreement with existing literature. Additionally, we propose new results which open up new perspectives towards multiscale and multiphysics analysis of cell assemblies, modelling a biological tissue.
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Submitted on : Tuesday, June 29, 2021 - 7:30:48 PM
Last modification on : Monday, October 11, 2021 - 2:23:44 PM
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  • HAL Id : tel-03274239, version 1

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Danish Shamoon. Multiscale and Multiphysics analysis of the deformation of cellular arrangements under an electric-field excitation : application to electroporation. Physics [physics]. Université de Bretagne occidentale - Brest, 2020. English. ⟨NNT : 2020BRES0028⟩. ⟨tel-03274239⟩

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