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Automated brain MRI metrics in the EPIRMEX cohort of preterm newborns: Correlation with the neurodevelopmental outcome at 2 years

Baptiste Morel 1 Pierre Bertault Géraldine Favrais 2 Elsa Tavernier 3 Barthelemy Tosello 4 Nathalie Bednarek 5 Laurent Barantin 2 Alexandra Chadie Maia Proisy 6 Yongchao Xu 7 Isabelle Bloch 8, 9, 10, 11 Dominique Sirinelli Catherine Adamsbaum Clovis Tauber Elie Saliba
1 CHRU Tours - Centre Hospitalier Régional Universitaire de Tours
2 iBrain - Inserm U1253 - UNIV Tours - Imagerie et cerveau
3 SPHERE - MethodS in Patients-centered outcomes and HEalth ResEarch
4 ADES - Anthropologie bio-culturelle, Droit, Ethique et Santé
5 CRESTIC - Centre de Recherche en Sciences et Technologies de l'Information et de la Communication - EA 3804
6 Département de Radiologie [Rennes]
7 LRDE - Laboratoire de Recherche et de Développement de l'EPITA
8 LTCI - Laboratoire Traitement et Communication de l'Information
9 LFI - Learning, Fuzzy and Intelligent systems
LIP6
10 IMAGES - Image, Modélisation, Analyse, GEométrie, Synthèse
LTCI - Laboratoire Traitement et Communication de l'Information
11 IDS - Département Images, Données, Signal
Abstract : Purpose The purpose of this study was to identify in the EPIRMEX cohort the correlations between MRI brain metrics, including diffuse excessive high signal intensities (DEHSI) obtained with an automated quantitative method and neurodevelopmental outcomes at 2 years. Materials and methods A total of 390 very preterm infants (gestational age at birth ≤ 32 weeks) who underwent brain MRI at term equivalent age at 1.5T (n=338) or 3T (n=52) were prospectively included. Using a validated algorithm, automated metrics of the main brain surfaces (cortical and deep gray matter, white matter, cerebrospinal fluid) and DEHSI with three thresholds were obtained. Linear adjust regressions were performed to assess the correlation between brain metrics with the ages and stages questionnaire (ASQ) score at 2 years. Results Basal ganglia and thalami, cortex and white matter surfaces positively and significantly correlated with the global ASQ score. For all ASQ sub-domains, basal ganglia and thalami surfaces significantly correlated with the scores. DEHSI was present in 289 premature newborns (74%) without any correlation with the ASQ score. Metrics of DEHSI were greater at 3T than at 1.5T. Conclusion Brain MRI metrics obtained in our multicentric cohort correlate with the neurodevelopmental outcome at 2 years of age. The quantitative detection of DEHSI is not predictive of adverse outcomes. Our automated algorithm might easily provide useful predictive information in daily practice.
Keywords : Cohort studies Brain Magnetic resonance imaging Premature White matter
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Journal articles
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https://hal.telecom-paris.fr/hal-03324508
Contributor : Isabelle Bloch Connect in order to contact the contributor
Submitted on : Monday, August 23, 2021 - 4:31:08 PM
Last modification on : Friday, January 14, 2022 - 5:24:02 PM

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ANTHROPO-MARSEILLE | UNIV-RENNES1 | INSTITUT-TELECOM | URCA | UNIV-NANTES | UNIV-RENNES | UNIV-AMU | UNIV-TOURS | IDS | IMAGES | LIP6 | LTCI | CNRS | CRESTIC | IP_PARIS | SPHERE_HEALTH_RESEARCH | SORBONNE-UNIVERSITE | SU-SCIENCES

Citation

Baptiste Morel, Pierre Bertault, Géraldine Favrais, Elsa Tavernier, Barthelemy Tosello, et al.. Automated brain MRI metrics in the EPIRMEX cohort of preterm newborns: Correlation with the neurodevelopmental outcome at 2 years. Diagnostic and Interventional Imaging, Elsevier, 2021, 102 (4), pp.225-232. ⟨10.1016/j.diii.2020.10.009⟩. ⟨hal-03324508⟩

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