We construct the interacting diffusion processes associated to determinantal processes on the whole space. Our construction is based on the notion of Dirichlet form and an integration by parts formula for functionals of determinantal processes on compact sets. We then prove the convergence of the Dirichlet forms on compact sets to a Dirichlet form defined on the whole space. We also prove the existence of diffusions associated with this limit Dirichlet form. Some examples of diffusions are also given.